In the 1980′s nitrates/nitrites and nitric oxide were considered a toxic environmental hazard, and any environmental hazard was thought to cause cancer. This idea has not left the popular press, and there were recommended daily allowances in an attempts to regulate amounts of dietary nitrates/nitrites. Nitrates were found in drinking water, and in particular in farm areas where levels of nitrates/nitrites were are used for fertilizer.
While today people think about at nitrates they often think about processed meats (bacon, hot dogs, antipasta, and other delicious charcuterie). Nitrites are the anti-bacterial agent desired for their anti-bacterial effect on food. But the highest levels of nitrates/nitrites are found in vegetables. But what is more fascinating is that the highest levels of nitrates are in human saliva.
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Your Body Uses Nitric Oxide Gas to Regulate Blood Vessels
One of the great discoveries in modern biochemistry/physiology is that our body uses nitrates. In fact, it uses nitric oxide, a gas, for regulation of blood pressure, digestion, and to prevent clotting, among other things.
The technical stuff: Sodium Nitrate is converted to Sodium Nitrite in our digestive system. The biochemistry is that dietary nitrate (NO(3)) and nitrite (NO(2)) are sources for the production of NO(x) which is a group of chemicals the body uses, such as nitric oxide (a gas – yes your body produces gas for some great things), and others such as nitrosothiols and nitroalkenes.
Dietary nitrates/nitrites, it turns out, are the building blocks for the material that is beneficial to the heart and blood vessels. Even the mechanism of action of drugs for erectile function, such as Viagra, increase nitric oxide in the vessels of the penis to help develop and maintain an erection. That our body uses nitric oxide to regulate blood vessels would never have been considered before its discovery in the 1990′s. So where, you might ask, is the controversy about nitrates?
What about Cancer and Nitrates?
There are a number of potential “carcinogenic” agents in processed meats. Nitrates do not appear to be them, and the entire discussion about processed meats and cancer needs some context.
Of all the types of scientific studies to perform, the population studies are the most difficult to use, because recalling amounts and types of foods is never easy. As we have reported before, these studies are prone to error unless there is very high statistical evidence that a link exists. For example: smoking with lung cancer had a relative risk of 20, but most of the population studies with humans show relative risk ratios of 1-2. The second difficulty with population studies is “processed meat” can be anything from bacon to cured sausage. As people eat more processed meats the relative risk goes up.
Colon cancer risk increases up to 140 g of processed meat a day, then flattens out. This figure taken from reference 4.
As you can see, the relative risk is real- and statistically it is a real trend, but it is not overwhelming. Look at the chart below. See the Relative Risk numbers for lung cancer as they increase with cigarettes. These are RR above 5, where the chart above shows RR below 1.5 at its highest. The important point is this: the factors in processed meats, if there are factors that increase cancer risk, are not anywhere near the increased risk of developing lung cancer from tobacco. Some would argue that with a relative-risk ratio of less than 2, one cannot determine effect.
This table shows huge risks of increasing smoking to lung cancer- look at the relative risks from this, vs. processed meats and cancer. – this table from reference 12
The real question is this: is this “trend” from nitrates/nitrites or some other factor? Is the risk of getting cancer from processed meat outweighed by the health benefits in maintaining the NO(x) levels needed? Some would note that nitrate-containing foods such as fruits, leafy green vegetables provide enough for the body to maintain NO(x) levels without the risk of colo-rectal cancers from the vegetarian group.
Are Vegetarians More at Risk than Bacon Eaters?
Here is the fun part of population studies. With processed meats the relative risk of colorectal cancer is mildly elevated, what about vegetarians and nitrates? Turns out they consume more nitrates than people who eat processed meats. But before we make the assumption about vegetarianism, or whole food plant diets, and cancer, we have to look at the real data. For example, fiber is primarily from vegetable sources, and it is the breakdown of that fiber by bacteria that provide us with chemicals that reduce colo-rectal cancer, one has to wonder if the answer is for meat eaters to increase fiber. Besides fiber, plants provide phytochemicals and other micronutrients that are associated with decreasing cancer in the laboratory, as well as in some human studies. Supplements do not provide this support (eat the food, don’t take the supplement).
BOTTOM LINE:
Candied bacon- maybe not a balanced diet, but close
If you are a fan of charcuterie, as I am, know that nitrites are the best way to prevent bacteria, especially botulism. If you buy nitrate -free products, they are at a higher risk. But more important, A balanced diet contains more than just processed meats. Nitrates/nitrites are probably not the issue- if there is an issue. Eat more fruits and vegetables.
REFERENCES:
(1) Hord NG. Dietary nitrates, nitrites, and cardiovascular disease. Curr Atheroscler Rep. 2011 Dec;13(6):484-92. PMID: 21968645
(2) Milkowski A, Garg HK, Coughlin JR, Bryan NS. Nutritional epidemiology in the context of nitric oxide biology: a risk-benefit evaluation for dietary nitrite and nitrate. Nitric Oxide. 2010 Feb 15;22(2):110-9.PMID: 19748594
(3) Hord NG, Tang Y, Bryan NS. Food sources of nitrates and nitrites: the physiologic context for potential health benefits.Am J Clin Nutr. 2009 Jul;90(1):1-10.PMID: 19439460
(4) Chan DS, Lau R, Aune D, Vieira R, Greenwood DC, Kampman E, Norat T. Red and processed meat and colorectal cancer incidence: meta-analysis of prospective studies.PLoS One. 2011;6(6):e20456. PMID: 21674008
(5) Tyrovolas S, Panagiotakos DB. The role of Mediterranean type diet on the development of cancer and cardiovascular disease, in the elderly: a systematic review. J Maturitas. 2009;65(2):122–130.
(6) World Cancer Research Fund/American Institute for Cancer Research. Food, nutrition, physical activity, and the prevention of cancer: a global perspective. Washington DC: AICR; 2007. pp. 22–25.
(7) Craig WJ. Health effects of vegan diets. Am J Clin Nutr. 2009;89(Suppl):1627S–1633S
(8) Divisi D, Di Tommaso S, Salvemini S, Garramone M, Crisci R. Diet and cancer. Acta Biomed. 2006:118–123.
(9) Dewell A, Weidner G, Sumner MD, Chi CS, Ornish D. A very-low fat vegan diet increases intake of protective dietary factors and decreases intake of pathogenic dietary factors. J Am Diet Assoc. 2008;108:347–356.
(10) Key TJ, Appleby PH, Spencer EA, et al. Cancer incidence in British vegetarians. Br J Cancer. 2009;101:192–197
(11) Fraser GE. Associations between diet and cancer, ischemic heart disease, and all-cause mortality in non-Hispanic white California Seventh-day Adventists. Am J Clin Nutr. 1999;70(Suppl):532S–538S.
(12) The graf reproduced from this source: http://www.cancerresearchuk.org/cancer-info/cancerstats/causes/lifestyle/tobacco/tobacco-and-cancer-risk
