By using this site, you agree to the Privacy Policy and Terms of Use.
Accept
Health Works CollectiveHealth Works CollectiveHealth Works Collective
  • Health
    • Mental Health
    Health
    Healthcare organizations are operating on slimmer profit margins than ever. One report in August showed that they are even lower than the beginning of the…
    Show More
    Top News
    improving patient experience
    6 Ways to Improve Patient Satisfaction Within Hospitals
    December 1, 2021
    degree for healthcare job
    What Are The Health Benefits Of Having A Degree?
    March 9, 2022
    custom software development is changing healthcare
    Digital Customer Journey Mapping and its Importance for Healthcare
    July 21, 2022
    Latest News
    Grounded Healing: A Natural Ally for Sustainable Healthcare Systems
    May 16, 2025
    Learn how to Renew your Medical Card in West Virginia
    May 16, 2025
    Choosing the Right Supplement Manufacturer for Your Brand
    May 1, 2025
    Engineering Temporary Hospitals for Extreme Weather
    April 24, 2025
  • Policy and Law
    • Global Healthcare
    • Medical Ethics
    Policy and Law
    Get the latest updates about Insurance policies and Laws in the Healthcare industry for different geographical locations.
    Show More
    Top News
    Can Thinking Younger Make You Live Longer?
    April 20, 2011
    Image
    Obesity’s Outlook Unchanged
    June 13, 2011
    When It’s An Emergency Elderly Not Treated As Well in Hospitals
    July 16, 2011
    Latest News
    Building Smarter Care Teams: Aligning Roles, Structure, and Clinical Expertise
    May 18, 2025
    The Critical Role of Healthcare in Personal Injury Recovery: A Comprehensive Guide for Victims
    May 14, 2025
    The Backbone of Successful Trials: Clinical Data Management
    April 28, 2025
    Advancing Your Healthcare Career through Education and Specialization
    April 16, 2025
  • Medical Innovations
  • News
  • Wellness
  • Tech
Search
© 2023 HealthWorks Collective. All Rights Reserved.
Reading: Hormone Therapy for Traumatic Brain Injuries
Share
Notification Show More
Font ResizerAa
Health Works CollectiveHealth Works Collective
Font ResizerAa
Search
Follow US
  • About
  • Contact
  • Privacy
© 2023 HealthWorks Collective. All Rights Reserved.
Health Works Collective > Technology > Medical Innovations > Hormone Therapy for Traumatic Brain Injuries
Medical InnovationsSpecialtiesTechnology

Hormone Therapy for Traumatic Brain Injuries

Deanna Pogorelc
Last updated: September 8, 2013 8:11 am
Deanna Pogorelc
Share
4 Min Read
SHARE

traumatic brain injuryOriginally published on MedCityNews.com. Put aside what you think you know about the sex hormone progesterone and consider this: It could be the foundation for a drug treatment for traumatic brain injury.

traumatic brain injuryOriginally published on MedCityNews.com. Put aside what you think you know about the sex hormone progesterone and consider this: It could be the foundation for a drug treatment for traumatic brain injury.

BHR Pharma said Tuesday that it’s completed enrollment in a Phase III safety and efficacy study of its progesterone formulation, BHR-100, as a neuroprotective agent for people who experience moderate to severe traumatic brain injury.

Started back in June of 2010, the SyNAPSe trial has extended the experimental therapy to nearly 1,200 TBI patients at 150 participating sites in the U.S., Israel, Argentina and 18 other countries in Europe and Asia. Patients in the trial received a five-day continuous IV infusion of progesterone beginning within eight hours of injury, the company says.

More Read

How to Identify and Treat Psoriasis
The Importance of Being on the Same Page
Medical Device Marketers: Let Digital DTP Turn You into a Sales Hero
6 Common Orthopedic Procedures
Artificial Intelligence for Healthcare: Are We There Yet?

The primary goal is to see improved outcomes six months after injury using the Glasgow Outcome Scale. Results for the trial, which has been done in conjunction with the American Brain Injury Consortium and the European Brain Injury Consortium, are expected in May 2014. A company representative could not be reached for additional comments on Tuesday.

Although it’s most commonly known for its role in regulating certain functions of ovulation and menstruation in women, progesterone therapy has also been found to affect the central nervous system of both men and women. In research studies, progesterone has demonstrated neuroprotective effects resulting in less brain swelling, less cell death in the brain and increased survival compared to a placebo.

If the drug meets its endpoints in this trial, it could be on its way to becoming the first drug treatment for TBI, which results in an estimated 1.5 million visits to the emergency room and 52,000 deaths in the U.S. each year. Current treatments for TBI involve emergency surgery or focus on preventing further injury, relieving symptoms or promoting rehabilitation.

Despite scientists’ great strides in understanding the course of TBI over the last few decades, a slew of promising pre-clinical therapies have failed to live up to expectations in human trials. Despite working against a backdrop of failed clinical trials, BHR has a few things going for it. Don Stein, the Emory University professor behind the work in TBI and progesterone, told the Washington Business Journal in 2009 that the treatment works at a number of different levels rather than targeting a specific mechanism, as most other trials have.

Regulators in the U.S. and EU have both given orphan drug status to BHR Pharma’s candidate, which was licensed from Emory University in 2009. The company formed near Washington D.C. in 2008 as an R&D subsidiary of Besins Healthcare, which markets progesterone, estrogen and testosterone therapy products in more than 90 countries.

[Image credit: FreeDigitalPhotos user moggara12]

Share This Article
Facebook Copy Link Print
Share

Stay Connected

1.5kFollowersLike
4.5kFollowersFollow
2.8kFollowersPin
136kSubscribersSubscribe

Latest News

Clinical Expertise
Building Smarter Care Teams: Aligning Roles, Structure, and Clinical Expertise
Health care
May 18, 2025
Grounded Healing: A Natural Ally for Sustainable Healthcare Systems
Grounded Healing: A Natural Ally for Sustainable Healthcare Systems
Health
May 15, 2025
Learn how to Renew your Medical Card in West Virginia
Learn how to Renew your Medical Card in West Virginia
Health
May 15, 2025
Dr. Klaus Rentrop Shares Acute Myocardial Infarction heart treatment
Dr. Klaus Rentrop Shares Acute Myocardial Infarction
Cardiology
May 13, 2025

You Might also Like

FDA Approvs for New Blood Thinner For Knee and Hip Replacements

July 3, 2011

September 26-28 AdvaMed 2011

August 25, 2011
Medical InnovationsNewsRadiologySpecialtiesTechnology

MRI Intervention’s Clearpoint Technology: The Future of MRI-Guided Surgery?

June 8, 2012
eHealthMedical DevicesMobile HealthTechnology

8 Health & Safety Apps & Devices to Recommend to Your Patients

September 13, 2018
Subscribe
Subscribe to our newsletter to get our newest articles instantly!
Follow US
© 2008-2025 HealthWorks Collective. All Rights Reserved.
  • About
  • Contact
  • Privacy
Welcome Back!

Sign in to your account

Username or Email Address
Password

Lost your password?