By using this site, you agree to the Privacy Policy and Terms of Use.
Accept
Health Works CollectiveHealth Works CollectiveHealth Works Collective
  • Health
    • Mental Health
    Health
    Healthcare organizations are operating on slimmer profit margins than ever. One report in August showed that they are even lower than the beginning of the…
    Show More
    Top News
    stress management for healthcare workers
    3 Tips For Healthcare Professionals: How To Stay Beautiful, Healthy, and Happy
    November 2, 2021
    importance of relaxing on the weekend for your health
    Importance of Relaxing During the Weekend for Optimal Health
    March 25, 2022
    LASIK Eye Surgery
    What Is LASIK Eye Surgery?
    May 16, 2022
    Latest News
    5 Steps to a Promising Career as a Healthcare Administrator
    July 31, 2025
    Why Custom Telemedicine Apps Outperform Off‑the‑Shelf Solutions
    July 20, 2025
    How Probate Planning Shapes the Future of Your Estate and Family Care
    July 17, 2025
    Beyond Nutrition: Everyday Foods That Support Whole-Body Health
    June 15, 2025
  • Policy and Law
    • Global Healthcare
    • Medical Ethics
    Policy and Law
    Get the latest updates about Insurance policies and Laws in the Healthcare industry for different geographical locations.
    Show More
    Top News
    You Probably Thought the Public Option Was Dead
    June 1, 2011
    Employers as Doctors
    July 9, 2011
    Pushback On My Medicare Proposals
    August 12, 2011
    Latest News
    How IT and Marketing Teams Can Collaborate to Protect Patient Trust
    July 17, 2025
    How Health Choices and Legal Actions Intersect After an Injury
    July 17, 2025
    How communities and healthcare providers can address slip and fall injuries with legal awareness
    July 17, 2025
    Let Your Lawyer Handle the Work Before You Pay Medical Costs
    July 6, 2025
  • Medical Innovations
  • News
  • Wellness
  • Tech
Search
© 2023 HealthWorks Collective. All Rights Reserved.
Reading: Hormone Therapy for Traumatic Brain Injuries
Share
Notification Show More
Font ResizerAa
Health Works CollectiveHealth Works Collective
Font ResizerAa
Search
Follow US
  • About
  • Contact
  • Privacy
© 2023 HealthWorks Collective. All Rights Reserved.
Health Works Collective > Technology > Medical Innovations > Hormone Therapy for Traumatic Brain Injuries
Medical InnovationsSpecialtiesTechnology

Hormone Therapy for Traumatic Brain Injuries

Deanna Pogorelc
Deanna Pogorelc
Share
4 Min Read
SHARE

traumatic brain injuryOriginally published on MedCityNews.com. Put aside what you think you know about the sex hormone progesterone and consider this: It could be the foundation for a drug treatment for traumatic brain injury.

traumatic brain injuryOriginally published on MedCityNews.com. Put aside what you think you know about the sex hormone progesterone and consider this: It could be the foundation for a drug treatment for traumatic brain injury.

BHR Pharma said Tuesday that it’s completed enrollment in a Phase III safety and efficacy study of its progesterone formulation, BHR-100, as a neuroprotective agent for people who experience moderate to severe traumatic brain injury.

Started back in June of 2010, the SyNAPSe trial has extended the experimental therapy to nearly 1,200 TBI patients at 150 participating sites in the U.S., Israel, Argentina and 18 other countries in Europe and Asia. Patients in the trial received a five-day continuous IV infusion of progesterone beginning within eight hours of injury, the company says.

More Read

Healthy Teeth is not an Option! It’s a way of Healthy Life
Is Your Health Organization Prepared for Accountable Care?
When Is External Peer Review The Right Choice For Hospitals?
Custom Lens Replacement: A Modern Vision Solution
3 Reasons Why Modern Communication Technology is Critical in Healthcare Industry

The primary goal is to see improved outcomes six months after injury using the Glasgow Outcome Scale. Results for the trial, which has been done in conjunction with the American Brain Injury Consortium and the European Brain Injury Consortium, are expected in May 2014. A company representative could not be reached for additional comments on Tuesday.

Although it’s most commonly known for its role in regulating certain functions of ovulation and menstruation in women, progesterone therapy has also been found to affect the central nervous system of both men and women. In research studies, progesterone has demonstrated neuroprotective effects resulting in less brain swelling, less cell death in the brain and increased survival compared to a placebo.

If the drug meets its endpoints in this trial, it could be on its way to becoming the first drug treatment for TBI, which results in an estimated 1.5 million visits to the emergency room and 52,000 deaths in the U.S. each year. Current treatments for TBI involve emergency surgery or focus on preventing further injury, relieving symptoms or promoting rehabilitation.

Despite scientists’ great strides in understanding the course of TBI over the last few decades, a slew of promising pre-clinical therapies have failed to live up to expectations in human trials. Despite working against a backdrop of failed clinical trials, BHR has a few things going for it. Don Stein, the Emory University professor behind the work in TBI and progesterone, told the Washington Business Journal in 2009 that the treatment works at a number of different levels rather than targeting a specific mechanism, as most other trials have.

Regulators in the U.S. and EU have both given orphan drug status to BHR Pharma’s candidate, which was licensed from Emory University in 2009. The company formed near Washington D.C. in 2008 as an R&D subsidiary of Besins Healthcare, which markets progesterone, estrogen and testosterone therapy products in more than 90 countries.

[Image credit: FreeDigitalPhotos user moggara12]

Share This Article
Facebook Copy Link Print
Share

Stay Connected

1.5kFollowersLike
4.5kFollowersFollow
2.8kFollowersPin
136kSubscribersSubscribe

Latest News

5 Steps to a Promising Career as a Healthcare Administrator
5 Steps to a Promising Career as a Healthcare Administrator
Health
July 31, 2025
holistic dental
Holistic Dentist Services Are Natural and Safe
Dental health Specialties
July 28, 2025
botox certification
Help Improve People’s Skin Health Via Botox Certification
Skin Specialties
July 22, 2025
Telemedicine Apps
Why Custom Telemedicine Apps Outperform Off‑the‑Shelf Solutions
Health
July 20, 2025

You Might also Like

Prostate Cancer: Wishing for Clear Answers Where There Are Few

December 1, 2012
virtual medical assistant
Technology

It’s Here! VMeDx Virtual Medical Assistant Aids in Healthcare

May 5, 2024
transparent payment systems for patient engagement
BusinessFinanceHealth ReformHospital AdministrationMedical DevicesMedical RecordsMobile HealthPolicy & LawPublic HealthTechnologyWellness

Can I Have My Receipt? Transparent Payment Systems Ignite Patient Engagement

November 10, 2013

The Vatican Invests in Stem Cell Company

November 9, 2011
Subscribe
Subscribe to our newsletter to get our newest articles instantly!
Follow US
© 2008-2025 HealthWorks Collective. All Rights Reserved.
  • About
  • Contact
  • Privacy
Welcome Back!

Sign in to your account

Username or Email Address
Password

Lost your password?