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Radiofrequency Ablation Systems Drive a Multi-billion Dollar Market

2 Mins read

One of the most active areas of development (products and market) in the field of ablation technology is in radiofrequency ablation systems. Currently at over $1.5 billion in sales globally, radiofrequency ablation sales will exceed $7 billion by 2019. Radiofrequency ablation devices work by sending alternating current through the tissue. This creates increased intracellular temperatures and localized interstitial heat. When temperatures exceed 60°C, cell proteins rapidly denature and coagulate, resulting in a lesion. The lesion can be used to resect and remove the tissue or to simply destroy the tissue, leaving the ablated tissue in place. Due to adverse effects such as charring, as well as perceived limitations on the use of RF devices, improvements have been developed and marketed which are designed to better control and direct the high temperatures produced at the tip of the RF device. These include so-called temperature controlled and fluid (saline or water) cooled versions. Temperature Controlled. One way to control the temperature at the tip of the RF electrode is to build in a feedback mechanism between the tip of the device and the RF generator. For example, in a device such as Covidien’s Cool-tip system, the RF generator was designed with a feedback algorithm. This algorithm senses tissue impedance and automatically delivers the best amount of radiofrequency energy for the situation. The Cool-tip’s electrode design serves further to eliminate tissue charring while allowing delivery of the maximum amount of energy, resulting in the ability to ablate a larger zone of tissue more quickly. Fluid Cooled. In the highly-popular fluid-cooled devices, the electrode’s internal circulation of water cools the tissue adjacent to the exposed electrode, maintaining low impedance during the treatment cycle. Low impedance permits maximum energy deposition for a larger ablation volume. It also decreases the risk of charring, and allows the surgeon to work faster. Catheter Manipulation Systems. Another recent development is the use of routine RF electrophysiology catheters in conjunction with a robotic catheter manipulation system, for both diagnostic and ablative EP applications. Examples of such systems include Catheter Robotics’ Remote Catheter Manipulation System, Hansen Medical’s Artisan Control Catheter/Sensei Robotic Catheter System, and Stereotaxis’ Magnetic Navigation System. Benefits of such systems include use of a catheter which is already familiar to the EP; the ability to manipulate the catheter (once it has been inserted into the heart) via a system from outside of the zone of radiation, and thus eliminate the need to wear the lead aprons; and the EP can then guide the procedure while watching the EP monitors and x-ray images. Companies active in the marketing and/or development of radiofrequency ablation products include: Advanced Cardiac Therapeutics, AngioDynamics, Ardian, Arthrex, ArthroCare, Asthmatx, Atricure, Bard EP, BÂRRX Medical, Inc., Baylis Medical (Kimberly-Clark), Biosense Webster (JNJ), Biotronik, Boston Scientific, Bovie Medical, BSD Medical, BTL Industries, Inc., Cardima Inc., Celon AG, ConMed, Cook Medical, CoRepair, Covidien, Endosense, EndyMed Ltd., EP Limited, Erbe Elektromedizin GmbH, Estech, Halt Medical, Hansen Medical, Gyrus ACMI (Olympus), Hologic, Integra Radionics, Mederi Therapeutics, Inc., Medtronic, nContact Surgical, Inc., OrthoDynamix LLC, PEAK Surgical, Salient Surgical Technologies, Smith & Nephew, St. Jude Medical, Stereotaxis, Stryker Interventional Spine, Valleylab (Covidien), VNUS Medical Technologies (Covidien), and Voyage Medical


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I serve the interests of medical technology company decision-makers, venture-capitalists, and others with interests in medtech producing worldwide analyses of medical technology markets for my audience of mostly medical technology companies (but also rapidly growing audience of biotech, VC, and other healthcare decision-makers). I have a small staff and go to my industry insiders (or find new ones as needed) to produce detailed, reality-grounded analyses of current and potential markets and opportunities. I am principally interested in those core clinical applications served by medical devices, which are expanding to include biomaterials, drug-device hybrids and other non-device technologies either competing head-on with devices or being integrated with devices in product development. The effort and pain of making every analysis global in scope is rewarded by my audience's loyalty, since in the vast majority of cases they too have global scope in their businesses. Specialties: Business analysis through syndicated reports, and select custom engagements, on medical technology applications and markets in general/abdominal/thoracic surgery, interventional cardiology, cardiothoracic surgery, patient monitoring/management, wound management, cell therapy, tissue engineering, gene therapy, nanotechnology, and others.
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