By using this site, you agree to the Privacy Policy and Terms of Use.
Accept
Health Works CollectiveHealth Works Collective
  • Health
    • Mental Health
    Health
    Healthcare organizations are operating on slimmer profit margins than ever. One report in August showed that they are even lower than the beginning of the…
    Show More
    Top News
    healthcare cybersecurity
    4 Helpful Tips on How to Protect Your Medical Practice Against Cyber Attacks
    October 24, 2021
    Health Check Diagnosis Medical Condition Analysis Concept
    6 Health Woes With Online Remedies
    January 19, 2022
    Eight Things Men Should Know About the Male Menopause
    Eight Things Men Should Know About the Male Menopause
    April 24, 2022
    Latest News
    The 6 Most Common Injuries Resulting from Motorcycle Accidents
    January 30, 2023
    6 Essential Strategies for Improving Your Medical Practice
    January 25, 2023
    Staying Positive While Living with Mesothelioma
    January 24, 2023
    The Many Health Benefits of Being Outdoors
    January 17, 2023
  • Policy and Law
    • Global Healthcare
    • Medical Ethics
    Policy and Law
    Get the latest updates about Insurance policies and Laws in the Healthcare industry for different geographical locations.
    Show More
    Top News
    Ultraprocessed Foods Lead to Chronic Illnesses
    April 18, 2011
    Cancer/Cell Phone Connection Challenged
    June 7, 2011
    States Ranked by Percent Obese Highlights Pervasive Negative Trend
    July 11, 2011
    Latest News
    Why Is a Referenced Based Pricing Tool Necessary?
    February 3, 2023
    Simplifying the Genetic Testing Process: How At-Home Kits are Changing the Game
    January 25, 2023
    9 Hospitals That Have Introduced Green Initiatives
    February 1, 2023
    Why a Health Retreat Can Be the Best Medicine
    January 12, 2023
  • Medical Innovations
  • News
  • Wellness
  • Tech
Search
© 2023 HealthWorks Collective. All Rights Reserved.
Reading: Does Disclosure Work?
Share
Sign In
Notification Show More
Latest News
Why Is a Referenced Based Pricing Tool Necessary?
Health care
struggling with addiction
6 Signs Someone You Know Is Struggling With Addiction
Addiction Addiction Recovery
regrow teeth naturally
Advances in Stem Cell Research Can Help Regrow Teeth Naturally
Dental health
air pollution and cancer
The Proven Links Between Air Pollution and Cancer
News
investing in senior care
5 Reasons Why Investing in Senior Care Is a Wise Choice?
Senior Care
Aa
Health Works CollectiveHealth Works Collective
Aa
Search
Have an existing account? Sign In
Follow US
  • About
  • Contact
  • Privacy
© 2023 HealthWorks Collective. All Rights Reserved.
Health Works Collective > Policy & Law > Public Health > Does Disclosure Work?
BusinessNewsPublic Health

Does Disclosure Work?

gooznews
Last updated: 2012/01/04 at 12:26 PM
gooznews
Share
5 Min Read
SHARE

Thanks to Larry Husten and the Cardiobrief blog for reprinting Harlan Krumholz’ New England Journal of Medicine article calling attention to a series of studies that show sponsors of a huge number of clinical trials, including those financed by the National Institutes of Health, are not divulging their results. Krumholz concludes:

Thanks to Larry Husten and the Cardiobrief blog for reprinting Harlan Krumholz’ New England Journal of Medicine article calling attention to a series of studies that show sponsors of a huge number of clinical trials, including those financed by the National Institutes of Health, are not divulging their results. Krumholz concludes:

The absence of the data renders meta-analyses, systematic reviews, and book chapters suspect. Conclusions are made on the basis of incomplete science. In short, publication bias and selective publication are impugning the validity of what we can learn from a PubMed search or even the most careful review of published studies.

The studies, which first appeared in the British Medical Journal, include:

More Read

tips to quit smoking

Quitting Smoking: 6 Tips to Help You Kick the Habit

Best Money-Saving Tips for Health Managers
Benefits of Buying Health Insurance for Your Adults
HR Must Navigate Polarizing Views in Healthcare Workplaces
Should Hospitals Use SASE or Traditional Network Security?

Ross et al: Despite recent improvement in timely publication, fewer than half of trials funded by NIH are published in a peer reviewed biomedical journal indexed by Medline within 30 months of trial completion. Moreover, after a median of 51 months after trial completion, a third of trials remained unpublished.

Hart et al: The effect of including unpublished FDA trial outcome data varies by drug and outcome.

Ahmed et al: Publication, availability, and selection biases are a potential concern for meta-analyses of individual participant data, but many reviewers neglect to examine or discuss them. These issues warn against uncritically viewing any meta-analysis that uses individual participant data as the most reliable.

Prayle et al: Most trials subject to mandatory reporting did not report results within a year of completion.

Wieland et al: Based on the results for 2005, at least 3000 records describing randomized controlled trials but not indexed using RCT may have been entered into Medline between 2006 and 2011.

The studies led by Ross and Prayle suggest that NIH-funded researchers are violating a law passed several years ago requiring publication of their results in a database. Did NIH fail to follow through on enforcing this requirement? Some enterprising reporter should investigate the possibility that investigators financed by the nation’s premier medical science research agency are violating this requirement wholesale.

This would appear to be one more example of where disclosure requirements, if unaccompanied by meaningful penalties, fail as a tool for policing bad behavior. In our age of hyper-commercialization and scientific competition, is sunlight still the best disinfectant, as Supreme Court Justice Louis Brandeis wrote in the early 20th century? Sometimes bleach works better. As Tracy Weber and Charles Ornstein of ProPublica reported yesterday, drug industry payments to physician “thought leaders” are slowing, not just because of greater disclosure, but because leading academic medical centers are cracking down on violators of their stricter policies limiting those payments.

The government cannot demand disclosure by investigators in privately-sponsored clinical trials. But NIH and the Food and Drug Administration, which receives data as part of new drug applications, can and should. If government-funded investigators fail to publish all their results in a timely manner — one year after the conclusion of a clinical trial seems reasonable — they should be barred from receiving new grants for at least three years. And companies that seek government approval for new drugs or expanded indications for old drugs should no longer be given the shield of “confidential business information” for any trial at the Phase II or III level, whether the drug or device is approved or not. Business matters, but public health and the accuracy of the science that informs it are more important.

TAGGED: clinical trials, NIH

Sign Up For Daily Newsletter

Be keep up! Get the latest breaking news delivered straight to your inbox.
By signing up, you agree to our Terms of Use and acknowledge the data practices in our Privacy Policy. You may unsubscribe at any time.
gooznews January 4, 2012
Share this Article
Facebook Twitter Copy Link Print
Share
Previous Article Health Care Social Media – How to Engage Online Without Getting into Trouble (Part I)
Next Article Employee Makes Fun of Patient on Facebook

Stay Connected

1.5k Followers Like
4.5k Followers Follow
2.8k Followers Pin
136k Subscribers Subscribe

Latest News

Why Is a Referenced Based Pricing Tool Necessary?
Health care February 3, 2023
struggling with addiction
6 Signs Someone You Know Is Struggling With Addiction
Addiction Addiction Recovery February 2, 2023
regrow teeth naturally
Advances in Stem Cell Research Can Help Regrow Teeth Naturally
Dental health February 1, 2023
air pollution and cancer
The Proven Links Between Air Pollution and Cancer
News February 1, 2023

You Might also Like

air pollution and cancer
News

The Proven Links Between Air Pollution and Cancer

February 1, 2023
stablecoins in healthcare
News

Stablecoins May Change the Future of Healthcare Billing

January 30, 2023
at-home genetic testing method kits
Global Healthcare

Simplifying the Genetic Testing Process: How At-Home Kits are Changing the Game

January 25, 2023
home safety tips
News

9 Tips to Minimize Injury Risks and Live Peacefully at Home

January 23, 2023
//

We influence million of users and is the most authentic source of information on healthcare business and technology news.

Quick Links

  • About
  • Contact
  • Privacy
Subscribe

Subscribe to our newsletter to get our newest articles instantly!

Follow US

© 2008-2023 HealthWorks Collective. All Rights Reserved.

Removed from reading list

Undo
Welcome Back!

Sign in to your account

Lost your password?