By using this site, you agree to the Privacy Policy and Terms of Use.
Accept
Health Works CollectiveHealth Works CollectiveHealth Works Collective
  • Health
    • Mental Health
    Health
    Healthcare organizations are operating on slimmer profit margins than ever. One report in August showed that they are even lower than the beginning of the…
    Show More
    Top News
    Things You Should Know Before Buying Golden Teacher Mushrooms Spores
    Things You Should Know Before Buying Golden Teacher Mushrooms Spores
    September 15, 2022
    difference between triglycerides and cholesterol
    What is the Difference Between Triglyceride and Cholesterol?
    December 14, 2022
    All-On-4 Dental Implant Surgery: A Guide to the Recovery Process
    All-On-4 Dental Implant Surgery: A Guide to the Recovery Process
    March 22, 2023
    Latest News
    Health Benefits of Taking a Vacation to Reduce Your Stress
    September 27, 2023
    First Aid Training Enhancing Workplace Health and Safety
    September 25, 2023
    Beyond the Clinic: Medical Surveys Are a Roadmap to Passive Income for Doctors
    September 23, 2023
    5 Self-Care Habits to Help You Live an A+ Life
    September 21, 2023
  • Policy and Law
    • Global Healthcare
    • Medical Ethics
    Policy and Law
    Get the latest updates about Insurance policies and Laws in the Healthcare industry for different geographical locations.
    Show More
    Top News
    Bone Density Tests – Too Many Not a Good Thing
    March 17, 2012
    HHS Empowers Patients to ‘Share the Health’ as Part of Reform Messaging Effort
    June 22, 2011
    Vitamin E Supplements May be Hazardous to Bone Health
    April 3, 2012
    Latest News
    Job Seekers with Disabilities Should at Health Insurance Benefits
    September 12, 2023
    Reasons That Drug Prices Are Rising to Unsustainable Levels
    September 12, 2023
    How Revenue Lifecycle Management Helps Healthcare Providers to Optimize Business Operations
    September 6, 2023
    The Hidden Benefits of Practice Exams for Medical Professionals
    September 6, 2023
  • Medical Innovations
  • News
  • Wellness
  • Tech
Search
© 2023 HealthWorks Collective. All Rights Reserved.
Reading: What You Need to Know About Exosomes Characterization
Share
Sign In
Notification Show More
Aa
Health Works CollectiveHealth Works Collective
Aa
Search
Have an existing account? Sign In
Follow US
  • About
  • Contact
  • Privacy
© 2023 HealthWorks Collective. All Rights Reserved.
Health Works Collective > News > What You Need to Know About Exosomes Characterization
News

What You Need to Know About Exosomes Characterization

Diana Hope
Last updated: 2022/03/10 at 7:39 PM
Diana Hope
Share
5 Min Read
exosomes in healthcare
Shutterstock Photo License - Meletios Verras
SHARE

We have seen a number of healthcare advances in recent years. The scientific community is starting to apply knowledge about bioparticles that have been discovered years ago that were largely ignored. One such example is the application of exosomes.

Contents
What Are Exosomes?Exosomes CharacterizationNanoparticle Tracking Analysis (NTA)-Based Exosome CharacterizationDynamic Light Scattering (DLS)Resistive Pulse SensingEndnote

Exosomes were discovered almost five decades ago, but the scientific community didn’t become interested in them until much later. Today, a growing number of publications are discussing them. Public interest about exosomes and their characterizations is also rising. Let’s take a deeper look into exosomes and what exosome characterization is.

What Are Exosomes?

Exosomes are nano extracellular vesicles containing various proteins, metabolites, nucleic acids, and lipids. Pan and Johnstone discovered exosomes as endocytic microvesicles secreted by maturing reticulocytes in the 1980s. Several cell types produce exosomes in both pathological and normal situations, and can be discovered in various physiological fluids.

Exosomes also give a view into changed cellular or tissue states since they transport many essential macromolecules. Their presence in fluids makes minimally invasive methods for liquid cultures with possible biomarkers for cancer prediction, diagnosis, and surveillance.

More Read

car accident injury

Small Car Accidents Can Cause Surprisingly Serious Injuries

Getting Compensation to Cover Car Accident Injury Bills
What Are the Side Effects of Using Durolane to Treat Knee Pain?
Drowning: Decoding the Timeframe of Survival in Water
Accidental Death Trends in Different U.S. States

Exosomes have long been thought of as cellular “trash bags,” a simple way to get rid of unwanted cellular waste products. Exosomes were not discovered to have a critical role in disease etiology until the mid-1990s. Exosomes offer significant clinical uses in developing innovative treatment techniques due to their biocompatibility and minimal immunogenicity and cytotoxicity.

Exosomes have a role in intercellular communication and act as critical molecular vehicles in controlling several physiological and pathological processes, including cancer formation and aging.

Exosomes Characterization

Exosomes have been characterized using various techniques, including biophysical, molecular, and microfluidic methods. The exosomal size range is characterized using biophysical techniques. Exosomes characterization methods include

  • Nanoparticle tracking analysis
  • Resistive pulse sensing
  • Dynamic light scattering
  • Electron microscopy
  • Flow cytometry
  • AFM

However, each of the above methods has its unique set of restrictions that needs to be considered. Let’s take a look at three widely used characterization methods.

Nanoparticle Tracking Analysis (NTA)-Based Exosome Characterization

The imaging and study of exosomes using nanoparticle tracking analysis is a highly sensitive method. The light dispersed from an exosome or microvesicle in liquid suspension is directly visualized using this method. A laser beam is carefully focused and passes through an optical interface, refracting through a small layer of material suspended in the liquid.

Dynamic Light Scattering (DLS)

Dynamic light scattering is also known as photon correlation spectroscopy. DLS is another method for determining exosome size. DLS operates on the premise of a monochromatic coherent laser beam passing through a particle suspension.

The time-dependent variations in breaking intensity generated by destructive and constructive interference caused by the relative Brownian motions of the bits inside a sample are then measured. Although this method is straightforward, it does not allow you to see the particles.

Resistive Pulse Sensing

Tunable resistive pulse sensing is a new method that has recently evolved. It’s best for determining the concentration and size distribution of exosomes and characterizing colloidal particles with diameters ranging from about 50 nm to the size of cells. This is crucial when studying cellular function. The single-particle concentration and characterization assessment of exosomes is a critical component of this approach.

Endnote

There have been a number of breakthroughs in healthcare technology over the last few years. One of the most impactful has been the discovery and application of exosomes. While they have been around for many years, we are starting to appreciate the importance in healthcare applications.

Exosomes’ physicochemical qualities, including size, shape, surface charge, density, and porosity, must be assessed to determine their biological interactions. The correct assessment of these properties is critical. Since exosome characterization is unique and consistent, determining whether the extracted components are exosomes necessitates numerous characterization indexes.

TAGGED: exosomes, healthcare advances, healthcare technology

Sign Up For Daily Newsletter

Be keep up! Get the latest breaking news delivered straight to your inbox.
By signing up, you agree to our Terms of Use and acknowledge the data practices in our Privacy Policy. You may unsubscribe at any time.
Diana Hope March 10, 2022
Share This Article
Facebook Twitter Copy Link Print
Share
Previous Article applied behavior analysis What Are the Benefits of ABA Therapy?
Next Article teeth whitening home remedies Crucial Tips for Choosing the Best Toothbrush

Stay Connected

1.5k Followers Like
4.5k Followers Follow
2.8k Followers Pin
136k Subscribers Subscribe

Latest News

Andropause hormonal decline
The Benefits of TRT for Andropause and Hormonal Decline
Wellness September 28, 2023
Cancer Prevention
The Importance of Lipoma Examination in Cancer Prevention
Cancer September 28, 2023
dental implant
Cost Analysis of Dental Implants in Australia
Dental health September 28, 2023
View,Of,Niagara,Falls,In,Autumn
Health Benefits of Taking a Vacation to Reduce Your Stress
Health September 27, 2023

You Might also Like

tips for neurodivergent people being pulled over
News

Tips for People with Neurodivergent Disorders Being Pulled Over

September 21, 2023
distress tolerance DBT
News

Why Healthcare Professionals Like Sherief Abu-Moustafa Support Strengthening Distress Tolerance Through DBT

September 10, 2023
best health apps
Technology

5 Tech Apps and Gadgets to Maintain Your Health Connectivity

August 31, 2023
hearing health and melbourne music scene
News

Melbourne’s Music Scene: A Symphony for Your Senses

August 31, 2023
Subscribe

Subscribe to our newsletter to get our newest articles instantly!

Follow US
© 2008-2023 HealthWorks Collective. All Rights Reserved.
  • About
  • Contact
  • Privacy
Welcome Back!

Sign in to your account

Lost your password?