By using this site, you agree to the Privacy Policy and Terms of Use.
Accept
Health Works CollectiveHealth Works CollectiveHealth Works Collective
  • Health
    • Mental Health
    Health
    Healthcare organizations are operating on slimmer profit margins than ever. One report in August showed that they are even lower than the beginning of the…
    Show More
    Top News
    benefits of using protein powder to build muscles
    Protein Powder for Muscle Mass: Everything You Need to Know
    December 12, 2021
    changes brought on by blockchain in healthcare
    Technology In The Healthcare Industry
    March 28, 2022
    What Does Core Body Temperature Say About Health?
    August 17, 2022
    Latest News
    7 Most Common Healthcare Accreditation Programs: Which Should You Use?
    August 20, 2025
    Hospital Pest Control and the Fight Against Superbugs
    August 20, 2025
    Hygiene Beyond The Clinic: Attention To Overlooked Non-Clinical Spaces
    August 13, 2025
    5 Steps to a Promising Career as a Healthcare Administrator
    August 3, 2025
  • Policy and Law
    • Global Healthcare
    • Medical Ethics
    Policy and Law
    Get the latest updates about Insurance policies and Laws in the Healthcare industry for different geographical locations.
    Show More
    Top News
    Do Electronic Health Records Reduce Malpractice Claims?
    February 2, 2013
    A Humble Opinion: Book Review
    May 3, 2015
    medicaid
    Paul Krugman: Stop Being an Embarrassment to the Profession
    March 7, 2013
    Latest News
    How Social Security Disability Shapes Access to Care and Everyday Health
    August 22, 2025
    How a DUI Lawyer Can Help When Your Future Health Feels Uncertain
    August 22, 2025
    How One Fall Can Lead to a Long Road of Medical Complications
    August 22, 2025
    How IT and Marketing Teams Can Collaborate to Protect Patient Trust
    July 17, 2025
  • Medical Innovations
  • News
  • Wellness
  • Tech
Search
© 2023 HealthWorks Collective. All Rights Reserved.
Reading: Alzheimer’s Drug Development: An Avant-Garde Approach
Share
Notification Show More
Font ResizerAa
Health Works CollectiveHealth Works Collective
Font ResizerAa
Search
Follow US
  • About
  • Contact
  • Privacy
© 2023 HealthWorks Collective. All Rights Reserved.
Health Works Collective > Technology > Medical Innovations > Alzheimer’s Drug Development: An Avant-Garde Approach
Medical InnovationsSpecialties

Alzheimer’s Drug Development: An Avant-Garde Approach

Deanna Pogorelc
Deanna Pogorelc
Share
3 Min Read
SHARE

alzheimer's disease

Originally published on MedCityNews.com.

alzheimer's disease

Originally published on MedCityNews.com.

More Read

Image
Lung Cancer Part 4 – Drug Therapy
Modern Teeth Whitening Technologies Used by Clinics in Ireland
4 Tips For Relieving Stress As A Caregiver To Your Elderly Parents
Technology Applications and the Fast-Moving Elderly
How To Take Care Of Your Bone Health In Your Forties

A handful of high-profile Alzheimer’s disease drugs have failed in late-stage clinical trials in the last year — at least two of them based on the hypothesis that buildup of amyloid plaques in the brain give rise to neurodegeneration. Startup T3D Therapeutics Inc. thinks that warrants a different approach to a disease-altering therapeutic.

“Alzheimer’s disease involves multiple abnormalities, yet the pharmaceutical industry has placed heavy bets on developing treatments for just one abnormality,” said founder and CEO John Didsbury.

T3D claims it’s developing a drug with the potential to address several disease pathologies, including beta-amyloid plaque issues, inflammation, neuronal cell loss, neurotransmitter deficits, insulin deficiency and tau neurofibrillary tangles. And it would come in the form of a once-a-day pill for people with mild to moderate Alzheimer’s.

The Durham, North Carolina company licensed its technology from specialty pharmaceutical company DARA BioSciences, where Didsbury formerly served as president and chief operating officer. DARA had developed the drug candidate, now called T3D-959, through Phase I clinical trials as a treatment for diabetes and dyslipidemia. Thus, Didsbury said a key piece of T3D’s approach to altering the course of Alzheimer’s is insulin regulation.

Researchers have been studying a link between insulin dysregulation and Alzheimer’s for almost a decade. T3D sees insulin deficiency as a trigger for the abnormalities that lead to neurodegeneration.

“Clinical symptoms never occur without sugar metabolism decreases in the brain, which results from neurons becoming resistant to insulin,” he said. “Without the ability to use insulin to access sugar as an energy source, neurons die. T3D-959 acts as a powerful insulin sensitizer.”

Didsbury said the company just closed an oversubscribed seed round this summer, which SEC filings indicate targeted $550,000, and just opened a Series A round. “We will be using those funds to do pre-clinical trials and a pilot clinical trial in Alzheimer’s disease,” he said.

For his part, Didsbury has assembled a supporting cast of science and pharmaceutical business veterans and an advisory board that includes a key developer of Alzheimer’s drug Aricept and the chief of neurology at Duke University Medical Center. The CEO has served in the C-suites of several pharma companies over the last two decades, including NovaTarg and GlaxoSmithKline.

“It has been a personal mission of mine for the last 25 years in the pharmaceutical industry to identify and develop a breakthrough medicine,” Didsbury said. “This is the culmination of that search.”

[Image credit: Flickr user GreenFlames09]

TAGGED:Alzheimer's Diseasehealth start-ups!
Share This Article
Facebook Copy Link Print
Share

Stay Connected

1.5kFollowersLike
4.5kFollowersFollow
2.8kFollowersPin
136kSubscribersSubscribe

Latest News

engineer fitting prosthetic arm
How Social Security Disability Shapes Access to Care and Everyday Health
Health care
August 20, 2025
a woman explaining the document
How a DUI Lawyer Can Help When Your Future Health Feels Uncertain
Public Health
August 20, 2025
physiotherapist at work
How One Fall Can Lead to a Long Road of Medical Complications
Health care
August 20, 2025
Common Healthcare Accreditation Programs
7 Most Common Healthcare Accreditation Programs: Which Should You Use?
Health News
August 20, 2025

You Might also Like

Peripheral Vascular
CardiologyMedical Devices

Peripheral Vascular Stenting to 2020

February 10, 2016
Specialties

DHHS: Does this lie make me look stupid?

July 11, 2012
oral health
Dental healthSpecialties

What Causes Tooth Pain and How to Treat It

October 14, 2022
medical industry innovations
HealthMedical InnovationsMedicareTechnology

How is CNC Machining Transforming the Medical Industry?

June 2, 2022
Subscribe
Subscribe to our newsletter to get our newest articles instantly!
Follow US
© 2008-2025 HealthWorks Collective. All Rights Reserved.
  • About
  • Contact
  • Privacy
Welcome Back!

Sign in to your account

Username or Email Address
Password

Lost your password?