By using this site, you agree to the Privacy Policy and Terms of Use.
Accept
Health Works CollectiveHealth Works CollectiveHealth Works Collective
  • Health
    • Mental Health
  • Policy and Law
    • Global Healthcare
    • Medical Ethics
  • Medical Innovations
  • News
  • Wellness
  • Tech
Search
© 2023 HealthWorks Collective. All Rights Reserved.
Reading: Two Reasons Good News From Medical Trials is Often Overturned Later
Share
Notification Show More
Font ResizerAa
Health Works CollectiveHealth Works Collective
Font ResizerAa
Search
Follow US
  • About
  • Contact
  • Privacy
© 2023 HealthWorks Collective. All Rights Reserved.
Health Works Collective > Specialties > Two Reasons Good News From Medical Trials is Often Overturned Later
Specialties

Two Reasons Good News From Medical Trials is Often Overturned Later

DavidEWilliams
DavidEWilliams
Share
2 Min Read
SHARE

Medical trials that claim large effects from treatment are often followed by much less impressive results the more they are replicated or tried out in the real world. A new study reports two factors behind this, one of which is obvious, the other less so.

Medical trials that claim large effects from treatment are often followed by much less impressive results the more they are replicated or tried out in the real world. A new study reports two factors behind this, one of which is obvious, the other less so.

The first factor is that trials showing big effects are often performed with few trial participants. The small sizes make it a lot more likely that the results are based on chance. Follow-up studies tend to show a regression to the mean as the effect of chance is reduced. That’s the obvious one.

The other factor is that many of the large-effect studies are based on intermediate endpoints, such as lowering cholesterol, rather than more meaningful outcomes such as extension of life or prevention of heart attack.

More Read

holistic dental
Holistic Dentist Services Are Natural and Safe
Digital Tools for Clinical Trials
CBD: The Difference Between Full Spectrum And Isolate
How Big Data Can Be Used To Prevent Fatal Heart Attack
5 Numbers Essential to Your Kidney Health

In general patients and doctors should be skeptical when they hear about a trial showing great results. Look to see if it’s a big or small trial and what endpoint is being measured.

 


TAGGED:clinical trials
Share This Article
Facebook Copy Link Print
Share

Stay Connected

1.5kFollowersLike
4.5kFollowersFollow
2.8kFollowersPin
136kSubscribersSubscribe

Latest News

dental care
Importance of Good Dental Care for Health and Confidence
Dental health Specialties
October 2, 2025
AI in Healthcare
AI in Healthcare: Technology is Transforming the Global Landscape
Global Healthcare Policy & Law Technology
October 1, 2025
Choosing the Right Swimwear for Health and Safety
News
September 30, 2025
sports concussions
Concussion In Sports: How Common They Are And What You Need To Know
Infographics
September 28, 2025

You Might also Like

best sofas for back support
OrthopaedicsSpecialties

Best Sofas for Back Support & Relief from Bad Back Pain

August 18, 2021
Health careSpecialties

5 Self-Care Strategies For Dealing With Sugar Level Stress

March 18, 2020
Analytics
BusinessHospital AdministrationRadiology

Business Analytics for Radiology

January 1, 2015
global demand for cosmetic surgery
Global HealthcareSpecialties

The Persistence of Demand for Cosmetic Procedures

May 15, 2014
Subscribe
Subscribe to our newsletter to get our newest articles instantly!
Follow US
© 2008-2025 HealthWorks Collective. All Rights Reserved.
  • About
  • Contact
  • Privacy
Welcome Back!

Sign in to your account

Username or Email Address
Password

Lost your password?