By using this site, you agree to the Privacy Policy and Terms of Use.
Accept
Health Works CollectiveHealth Works CollectiveHealth Works Collective
  • Health
    • Mental Health
  • Policy and Law
    • Global Healthcare
    • Medical Ethics
  • Medical Innovations
  • News
  • Wellness
  • Tech
Search
© 2023 HealthWorks Collective. All Rights Reserved.
Reading: Protective Genetic Material Appears to Protect against Alzheimer Dementia
Share
Notification Show More
Font ResizerAa
Health Works CollectiveHealth Works Collective
Font ResizerAa
Search
Follow US
  • About
  • Contact
  • Privacy
© 2023 HealthWorks Collective. All Rights Reserved.
Health Works Collective > Specialties > Geriatrics > Protective Genetic Material Appears to Protect against Alzheimer Dementia
GeriatricsSpecialties

Protective Genetic Material Appears to Protect against Alzheimer Dementia

MichaelDouglas1
MichaelDouglas1
Share
3 Min Read
SHARE

The journal Nature is reporting in its latest issue of a protective genetic mutation that retards the production of one of the most commonly cited elements responsible for Alzheimer dementia — beta amyloid.

The journal Nature is reporting in its latest issue of a protective genetic mutation that retards the production of one of the most commonly cited elements responsible for Alzheimer dementia — beta amyloid.

 [T]o search for low-frequency variants in the amyloid-β precursor protein (APP) gene with a significant effect on the risk of Alzheimer’s disease, we studied coding variants in APP in a set of whole-genome sequence data from 1,795 Icelanders. We found a coding mutation (A673T) in the APP gene that protects against Alzheimer’s disease and cognitive decline in the elderly without Alzheimer’s disease. … The strong protective effect of the A673T substitution against Alzheimer’s disease provides proof of principle for the hypothesis that reducing the β-cleavage of APP may protect against the disease.

Great news for patients who can benefit from the even more grateful drug companies who will no doubt be rushing to develop therapies based upon this premise, first announced yesterday. As one can probably assume, most do not have the protective gene mutation, but as common as Alzheimer dementia is, most people do not acquire it. Also, most who develop Alzheimer’s do not have one of the rare gene mutations that cause it. The reasons for their disease are unclear. Perhaps even more importantly, the presence of the mutation appears to override a huge genetic risk factor for Alzheimer development — the ApoE4 allele. Scientists do stress, however, that testing for this biomarker will not predict who will eventually acquire degenerative dementia, as those who do have it just produce much less amyloid just like any one else who never acquired the disease. What this data does show is that beta amyloid production continues to be a central point from which much research into anti-Alzheimer therapies are being developed. Reducing the levels of this protein in known Alzheimer dementia is an ongoing goal of which this discovery is only a small part.

 

More Read

Image
On Use of Hypnosis for Treatment of PTSD
CBD 101: Things To Know About The Different Cannabis Compounds
Direct-to-Consumer Advertising Still Influences Prescribing
Tips for Hosting an Age-friendly Thanksgiving Dinner
Your Lifestyle Can Prevent Sudden Cardiac Death
TAGGED:Alzheimer's Disease
Share This Article
Facebook Copy Link Print
Share

Stay Connected

1.5kFollowersLike
4.5kFollowersFollow
2.8kFollowersPin
136kSubscribersSubscribe

Latest News

a woman walking on the hallway
6 Easy Healthcare Ways to Sit Less and Move More Every Day
Health
September 9, 2025
Clinical Expertise
Healthcare at a Crossroads: Why Leadership Matters More Than Ever
Global Healthcare
September 9, 2025
travel nurse in north carolina
Balancing Speed and Scope: Choosing the Nursing Degree That Fits Your Goals
Nursing
September 1, 2025
intimacy
How to Keep Intimacy Comfortable as You Age
Relationship and Lifestyle Senior Care
September 1, 2025

You Might also Like

Ophthalmology

What All Good Cataract Surgeons Have In Common

November 28, 2019

The “Luck of the Jewish” in Cancer

July 17, 2013
Dental healthHome Health

The Link Between Dental Health And Overall Health

June 15, 2020

The Human Side of Molecular Imaging

June 11, 2012
Subscribe
Subscribe to our newsletter to get our newest articles instantly!
Follow US
© 2008-2025 HealthWorks Collective. All Rights Reserved.
  • About
  • Contact
  • Privacy
Welcome Back!

Sign in to your account

Username or Email Address
Password

Lost your password?